Chondrogenesis of Human Infrapatellar Fat Pad Stem Cells on Acellular Dermal Matrix
نویسندگان
چکیده
منابع مشابه
Chondrogenesis of Human Infrapatellar Fat Pad Stem Cells on Acellular Dermal Matrix
Acellular dermal matrix (ADM) has been in clinical use for decades in numerous surgical applications. The ability for ADM to promote cellular repopulation, revascularisation and tissue regeneration is well documented. Adipose stem cells have the ability to differentiate into mesenchymal tissue types, including bone and cartilage. The aim of this study was to investigate the potential interactio...
متن کاملExtracellular Matrix Reprograms Adipose Stem Cells from Infrapatellar Fat Pad toward Chondrogenesis
Introduction Once damaged, articular cartilage has a limited capacity for self-repair. Autologous chondrocyte transplantation is one approach for cartilage defect repair, but donor source limitation and in vitro expansion senescence can be problematic. Compared with stem cells derived from bone marrow (BMSCs) and synovial membrane (SDSCs), adipose stem cells (ASCs) are easier to obtain, have re...
متن کاملThe infrapatellar fat pad from diseased joints inhibits chondrogenesis of mesenchymal stem cells.
Cartilage repair by bone marrow derived mesenchymal stem cells (MSCs) can be influenced by inflammation in the knee. Next to synovium, the infrapatellar fat pad (IPFP) has been described as a source for inflammatory factors. Here, we investigated whether factors secreted by the IPFP affect chondrogenesis of MSCs and whether this is influenced by different joint pathologies or obesity. Furthermo...
متن کاملChondrogenesis of Infrapatellar Fat Pad Derived Adipose Stem Cells in 3D Printed Chitosan Scaffold
Infrapatellar fat pad adipose stem cells (IPFP-ASCs) have been shown to harbor chondrogenic potential. When combined with 3D polymeric structures, the stem cells provide a source of stem cells to engineer 3D tissues for cartilage repair. In this study, we have shown human IPFP-ASCs seeded onto 3D printed chitosan scaffolds can undergo chondrogenesis using TGFβ3 and BMP6. By week 4, a pearlescen...
متن کاملFunctional properties of cartilaginous tissues engineered from infrapatellar fat pad-derived mesenchymal stem cells.
Articular cartilage has a poor intrinsic capacity for self-repair. The advent of autologous chondrocyte implantation has provided a feasible method to treat cartilage defects. However, the associated drawbacks with the isolation and expansion of chondrocytes from autologous tissue has prompted research into alternative cell sources such as mesenchymal stem cells (MSCs) which have been found to ...
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ژورنال
عنوان ژورنال: Frontiers in Surgery
سال: 2016
ISSN: 2296-875X
DOI: 10.3389/fsurg.2016.00003